Heterozygous BMP6 Variants Coupled With HFE Variants
نویسندگان
چکیده
منابع مشابه
Novel compound heterozygous NMNAT1 variants associated with Leber congenital amaurosis
PURPOSE The gene encoding nicotinamide nucleotide adenylyltransferase 1 (NMNAT1) was recently found to be mutated in a subset of patients with Leber congenital amaurosis (LCA) with macular atrophy. The aim of this study was to determine the occurrence and frequency of NMNAT1 mutations and associated phenotypes in different types of inherited retinal dystrophies. METHODS DNA samples of 161 pat...
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We investigate the security of a generalization of HFE (multivariate and odd-characteristic variants). First, we propose an improved version of the basic Kipnis-Shamir key recovery attack against HFE. Second, we generalize the Kipnis-Shamir attack to Multi-HFE. The attack reduces to solve a MinRank problem directly on the public key. This leads to an improvement of a factor corresponding to the...
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Iron accumulation in the brain and increased oxidative stress are consistent observations in many neurodegenerative diseases. Thus, we have begun examination into gene mutations or allelic variants that could be associated with loss of iron homeostasis. One of the mechanisms leading to iron overload is a mutation in the HFE gene, which is involved in iron metabolism. The 2 most common HFE gene ...
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We investigate in this paper the security of HFE and Multi-HFE schemes as well as their minus and embedding variants. Multi-HFE is a generalization of the well-known HFE schemes. The idea is to use a multivariate quadratic system – instead of a univariate polynomial in HFE – over an extension field as a private key. According to the authors, this should make the classical direct algebraic (mess...
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Heterozygous rare variants in the PINK1 gene, as well as in other genes causing autosomal recessive parkinsonism, have been reported both in patients and healthy controls. Their pathogenic significance is uncertain, but they have been suggested to represent risk factors to develop Parkinson disease (PD). The few large studies that assessed the frequency of PINK1 heterozygotes in cases and contr...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2016
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2016.02.088